Episode #47: meloxicam (Mobic) | Podcast Show Notes
meloxicam (mel OKS i kam)
Below will be links for the full Podcast and the Drug Card for meloxicam along with a brief summary of various points on meloxicam.Â
QUESTIONS:
- A 30 year old female with rheumatoid arthritis is in their third trimester of pregnancy. Which of the following is an appropriate dosing regimen?
- A). 7.5 mg PO bid
- B). 15 mg PO bid
- C). 7.5 mg PO qd
- D). 15 mg PO qd
- E). None of the above
- True or False. Meloxicam has less GI distress due to the irreversible selective inhibition of the COX1 enzyme with minimal COX2 enzyme inhibition.
- Which of the following is appropriate for meloxicam use in children? Select all that apply.
- A). Approved for idiopathic arthritis
- B). Approved for severe joint injuries
- C). In pts <60 kg 7.5 mg PO qd is appropriate
- D). In pts >60 kg 7.5 mg PO qd is appropriate
- E). None of the above.
SUMMARY:
Meloxicam is a nonsteroidal anti-inflammatory non-opioid analgesic medication used to treat osteoarthritis and rheumatoid arthritis. A treatment range is often between 5-15 mg PO qd with a max of 15 mg/day. Meloxicam works through reversible COX1/COX2 enzyme inhibition decreasing thromboxane and prostaglandins leading to antipyretic, anti-inflammatory, and analgesic effects. It is metabolized via the CYP2C9 and CYP3A4 pathways. The time to peak for tablets is around 4-5 hours with a half-life elimination of 13-22 hours. It should not be used during pregnancy and close to conception. Black Box Warning for cardiovascular thrombotic events and GI bleed/ulcerations/perforation. To avoid and minimize GI related issues take with food.
ANSWERS:Â Â
- E) is correct. Although C and D are within the appropriate dosing range, this patient is pregnant and meloxicam should not be used during pregnancy and close to conception.
- False. Meloxicam reversibly inhibits both the COX1 and COX2 enzymes.Â
- A and D are correct.
PDF of Drug Card: meloxicam
