Episode #13: cyclobenzaprine (Flexeril) | Podcast Show Notes
cyclobenzaprine (sye kloe BEN za preen)
Below will be links for the full Podcast and the Drug Card for cyclobenzaprine along with a brief summary of various points on cyclobenzaprine.
QUESTIONS:
- Flexeril is one of the most commonly known brand names for cyclobenzaprine. What is another?
- T or F: You should be concerned if a patient is using the OTC St. John’s wort while on cyclobenzaprine.
- T or F: Amrix works by acting peripherally on skeletal muscle on selectively reducing the gamma motor neuron activity.
- Select all that apply
- A). Short term usage is maxed at up to 7 days at a time
- B). Short term usage is between 2-3 weeks
- C). Both capsules and tablets should be taken whole
- D). Pediatric dosing has not been established
- Name one of the off-label indications for cyclobenzaprine?
SUMMARY:
Cyclobenzaprine is a skeletal muscle relaxant that goes by brand names Flexeril and Amrix. The drug’s effects are achieved through acting centrally on the skeletal muscle and reducing the motor activity of both the alpha and gamma motor neurons. Typical dosing is initiated at 5 mg po tid with one of the doses being at bedtime. The duration of therapy is short term being 2-3 weeks max. Can be taken with or without food. Capsules can be opened and sprinkled but tablets are recommended to be taken whole. The main drug interaction concerns are with CNS depressants, serotonin increasing drugs/agents, and w/ anticholinergics. Common side effects experienced by patients are dizziness, fatigue, and constipation. This drug is metabolized hepatically and requires dose adjustments in those with impaired hepatic function.
ANSWERS:
- Amrix or Fexmid are also brand names for cyclobenzaprine
- True – b/c concern is with serotonin affecting agents and Serotonin Syndrome
- False – Drug acts “centrally” on skeletal muscles and on “both” the alpha and gamma motor neuron
- B – “A” although 7 days is short, max is 2-3 weeks. “C” capsules can be opened. “D” established.
- Fibromyalgia or Transmandibular Disorder
PDF of Drug Card: cyclobenzaprine
