SUMMARY:

Haloperidol also known by the brand name Haldol is a first generation antipsychotic. Haldol is commonly used in the treatment of Psychosis and Tourette Syndrome. There is also an off label use for acute agitation. When using Haldol it is important to use the lowest effective dose. A common dosing range is between 0.5-2 mg which is taken by mouth and divided two to three times daily. In severe treatment cases the treatment range can be as high as 3-5 mg PO 2-3x daily. The mechanism of action is proposed to be from selective antagonism of dopamine D2 receptors. Haldol is widely distributed throughout the body and is 92% protein bound. There is a black box warning for dementia-related psychosis. Haldol is not approved in dementia-related psychosis due to an increased risk of cardiovascular or infectious events that can lead to mortality in elderly patients.