Episode #49: benazepril (Lotensin) | Podcast Show Notes
benazepril (ben AY ze pril)
Below will be links for the full Podcast and the Drug Card for benazepril along with a brief summary of various points on benazepril.Â
QUESTIONS:
- A patient is on benazepril. They are currently taking 40 mg PO tid for the treatment of hypertension. Select all that applies to this patient’s treatment.
- A). Hypertension is not an appropriate indication for benazepril
- B). Hypertension is an appropriate indication for benazepril
- C). 40 mg PO tid is an appropriate dosing regimen
- D). 40 mg PO tid is not an appropriate dosing regimen
- E). Only B and C are correct
- True or False. A female patient on benazepril recently was determined to be pregnant. It is okay to continue treatment until the 3rd trimester.
- How long should a patient wait to take benazepril if they just stopped Entresto?
- Describe benazepril’s mechanism of action.
SUMMARY:
Benazepril, also known as Lotensin, is an antihypertensive agent. It works by competitively inhibiting the conversion of angiotensin I to angiotensin II. The onset of action is between 1-2 hours. When treating hypertension the treatment range is between 10-40 mg PO qd-bid. When first initiating, start at 10 mg PO qd with a max of 80 mg per day. There is black box warning for fetal toxicity. Common side effects are cough, fatigue, dizziness, hypotension, and hyperuricemia. Benazepril should be stopped ASAP if the patient is pregnant due to risks of fetal injury and fetal death. Sone monitoring parameters are blood pressure, BUN, Cr, electrolytes, and WBCs.After sitting down or lying down for a period of time, avoid getting up to fast to avoid orthostatic hypotension.
ANSWERS:Â Â
- B and D are correct. C is incorrect because 50 mg PO tid exceeds the 80 mg/day max.
- False. Benazepril should be avoided during pregnancy. Risk of fetal/neonatal harm/death in not only the 3rd trimester, but the 2nd as well.Â
- 36 hours
- Benazepril competitively inhibits the conversion of angiotensin I to angiotensin II. Angiotensin II is a potent vasoconstrictor and decreasing it’s production decreases vasoconstriction.
