Episode #42: furosemide (Lasix) | Podcast Show Notes
furosemide (fyoor OH se mide)
Below will be links for the full Podcast and the Drug Card for furosemide along with a brief summary of various points on furosemide.Â
QUESTIONS:
- Select all that apply. Drug usage should be avoided or used with caution in the following patient(s)?
- A). Premature neonates
- B). Enlarged prostate
- C). Bladder obstruction
- D). SLE
- E). Only B and C are correct.
- Fill in the blank. Furosemide interferes with the _______ – binding co-transport system. It inhibits _______ and _______ resorption in the ascending Loop of Henle and proximal and distal tubules.
- A). Sodium, potassium, chloride
- B). Sodium, chloride, sodium
- C). Chloride, sodium, chloride
- D). Chloride, calcium, potassium
- E). None of the above
- True or False. Onset of action for diuresis occurs in 90-120 minutes.
- True or False. There is black box warning for fluid and electrolyte retention.
SUMMARY:
Furosemide is an antihypertensive loop diuretic drug. The main indications are for edema and hypertension with an off-label use for hypercalcemia. The general dosing range is between 40-120 mg per day with a max of 600 mg per day. The mechanism of action is it interferes with the chloride-binding co-transport system causing a natriuretic effect. It inhibits sodium and chloride resorption in the ascending Loop of Henle and the proximal and distal renal tubules. The onset of action for diuresis is around 30-60 minutes with symptomatic improvement of acute pulmonary edema occurs within 15-20 minutes. Caution should be observed in patients with electrolyte imbalances, the elderly, premature neonates, patients with gout, lupus, and diabetes. There is a black box warning for fluid and electrolyte loss if excessive amounts are used. When considering the drug interactions one should consider that furosemide is an OAT1 and OAT3 substrate, it may cause hypocalcemia, hypokalemia, hyponatremia, ototoxicity, and others.Â
ANSWERS:Â Â
- A, B, C, and D are correct. E is incorrect because it does not include A and D.Â
- C). Chloride, sodium, chloride
- False. Onset of action for diuresis occurs in 30-60 minutes.
- False. There is indeed a black box warning but it is for fluid and electrolyte loss (not retention).
PDF of Drug Card: furosemide
