Episode #15: ubrogepant (Ubrelvy) | Podcast Show Notes
ubrogepant (ue BROE je pant)
Below will be links for the full Podcast and the Drug Card for Ubrelvy along with a brief summary of various points on Ubrelvy.
QUESTIONS:
- T or F: Ubrelvy should be taken with a high-fat meal to increase absorption.
- T or F: Unlike sumatriptan, ubrogepant can not be taken for a second dose due to it’s long half-life of greater than 12 hours.
- Select all that apply:
- A). Ubrelvy comes in a 50 mg tablet
- B). Ubrelvy comes in a 50 mg capsule
- C). Ubrelvy comes in a 100 mg nasal spray
- D). Ubrelvy comes in a 100 mg tablet
- How many times can Ubrelvy be safely used in a month?
SUMMARY:
Ubrogepant is currently brand only and known as Ubrelvy. This drug is a Calcitonin Gene-Related Peptide (CGRP) Receptor Antagonist used to treat migraines. There are two tablet strengths being the 50 mg and 100 mg dose. Initiated begins between 50 – 100 mg po for one dose and may be repeated after 2 hours for one more dose. The max dose is 200 mg per day. Dose adjustments should be made in patients with renal and/or hepatic impairment. This drug is primarily metabolized hepatically through the CYP3A4 pathway. Strong inhibitors or inducers for CYP3A4 should be avoided or used with dose adjustments. Ubrelvy’s time to peak is around 1.5 hours with a half-life of 5-7 hours. Patients should be aware of drowsiness, and nausea and should not use drugs or substances that may enhance drowsiness such as alcohol. Ubrelvy can be taken with or without food and for best results not taken with a high-fat meal.
ANSWERS:
- False. Ubrelvy although it can be taken with or without food, a high-fat meal may increase absorption time by 2 hours.
- False. A second dose can be taken after 2 hours. The half-life is short between 5-7 hours.
- A and D are correct. Ubrelvy only comes in a 50 and 100 mg tablet.
- Ubrelvy can “safely” be used 8 times in a month. Anything beyond that has no safety data.
Did you get any wrong? Make sure to listen to this week’s episode and download the free Drug Card for Ubrelvy.
PDF of Drug Card: ubrogepant
