Episode #14: hydrochlorothiazide (Microzide) | Podcast Show Notes
hydrochlorothiazide (hye droe klor oh THYE a zide)
Below will be links for the full Podcast and the Drug Card for hydrochlorothiazide along with a brief summary of various points on hydrochlorothiazide.
QUESTIONS:
- T or F: Microzide may cause orthostatic hypertension.
- Select all that apply
- A). Blood pressure should be monitored while on this drug
- B). Sodium should be monitored while on this drug
- C). LFTs should be monitored while on this drug
- D). Oxygen levels should be monitored while on this drug
- T or F: In order to counteract effects of Microzide one should use an amphetamine
- Which is/are the preferred diuretic(s) in the treatment of edema? (Select all that apply)
- A). Microzide
- B). Furosemide
- C). Indapamide
- D). Chlorthalidone
SUMMARY:
Hydrochlorothiazide is a thiazide diuretic that goes by the brand name Microzide. The way this drug works is through the inhibition of sodium reabsorption in the distal tubules of the kidneys. The drug is most commonly used in the treatment of Edema but has other pharmacological uses. Typical edema treatment dosing is initiated at 25-100 mg po qd divided into 1-2 doses. Thiazide diuretics are not the preferred diuretic for edema but does have its place in therapy. There is a concern in patients with sulfonamide-derived drug allergies but this is often challenged. The drug is excreted in the urine with ~60% as unchanged drug. Common side effects are orthostatic hypotension, diarrhea, dizziness, and headache. Substances such as alcohol may enhance orthostatic hypotension. Blood pressure, sodium, potassium and BUN should be monitored while patients are on this drug.
ANSWERS:
- False – It may cause orthostatic hyPOtension. Not hyPERtension.
- A and B are correct
- False – Although amphetamines may counteract effects of Microzide that is not common practice and should not be done
- B is correct because it is the only loop diuretic listed. A, C, and D can be used but are not “preferred”
PDF of Drug Card: hydrochlorothiazide
